Decoding Genomics and Proteomics of SARS-CoV-2: Emerging Therapeutic Frontiers is a comprehensive exploration and decoding of the genetic and molecular intricacies of SARS-CoV-2, the virus responsible for the COVID-19 pandemic. This book delves into the genomic architecture, proteomic interactions, its immune reactions and the evolutionary dynamics of the virus, shedding light on its biological behavior and impact on human health. It provides an in-depth analysis of viral genomic and proteomic mechanisms ensuring its replication capabilities and transmission, immune evasion mechanisms, and the role of mutations in shaping disease severity and vaccine efficacy. With a strong focus on cutting-edge research, the book offers updated insights and comprehensive synthesis, discussing the molecular pathways exploited by SARS-CoV-2, detailing how the virus hijacks host cellular machinery to ensure its replication and persistence. It highlights key therapeutic targets, including viral proteases, RNA-dependent RNA polymerase, and spike protein interactions, which have paved the way for the development of vaccines, monoclonal antibodies, and antiviral drugs. Furthermore, the book examines cytokine and bradykinin storms, emphasizing their role in severe disease progression and potential immunomodulatory interventions. Bridging the gap between basic science and clinical application, Decoding SARS-CoV-2 serves as a vital resource for researchers, healthcare professionals, and policymakers. It offers insights into global pandemic management, genomic surveillance, and future preparedness for emerging infectious diseases. Through a synthesis of virology, immunology, and translational medicine, this book not only unravels the complexities of SARS-CoV-2 but also provides a roadmap for combating future viral threats with innovative therapeutics and precision medicine strategies.